Stimulation of steroidogenic acute regulatory protein (STAR) geneexpression by D‐aspartate in rat Leydig cells
Open Access
- 9 July 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 454 (3) , 317-320
- https://doi.org/10.1016/s0014-5793(99)00840-6
Abstract
D-aspartate and human chorionic gonadotropin act synergistically to increase testosterone production in purified rat Leydig cells, and D-aspartate stimulates testosterone synthesis even in the absence of human chorionic gonadotropin stimulation. In addition, D-aspartate enhances steady-state cellular mRNA and protein levels of steroidogenic acute regulatory protein, which is a key regulatory factor in gonadal and adrenal steroidogenesis. D-aspartate therefore appears to increase testosterone production in rat Leydig cells by stimulating steroidogenic acute regulatory protein gene expression. To our knowledge, this is the first report demonstrating a direct effect of D-aspartate on gene expression in mammalian cells.Keywords
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