Substitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo
- 30 September 2007
- Vol. 366 (2) , 361-376
- https://doi.org/10.1016/j.virol.2007.04.028
Abstract
No abstract availableKeywords
This publication has 49 references indexed in Scilit:
- Pausing during Reverse Transcription Increases the Rate of Retroviral RecombinationJournal of Virology, 2006
- Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H functionNucleic Acids Research, 2006
- Selective extraction of polyoma DNA from infected mouse cell culturesPublished by Elsevier ,2004
- Recognition of Internal Cleavage Sites by Retroviral RNases HJournal of Molecular Biology, 2004
- Substitutions of Phe61 Located in the Vicinity of Template 5′-Overhang Influence Polymerase Fidelity and Nucleoside Analog Sensitivity of HIV-1 Reverse TranscriptaseJournal of Biological Chemistry, 2002
- Identification of Residues of the Moloney Murine Leukemia Virus Nucleocapsid Critical for Viral DNA Synthesis In VivoJournal of Virology, 2001
- Structural alterations in the DNA ahead of the primer terminus during displacement synthesis by reverse transcriptasesJournal of Molecular Biology, 2001
- Properties of strand displacement synthesis by moloney murine leukemia virus reverse transcriptase: mechanistic implicationsJournal of Molecular Biology, 1998
- Reduced Frameshift Fidelity and Processivity of HIV-1 Reverse Transcriptase Mutants Containing Alanine Substitutions in Helix H of the Thumb SubdomainPublished by Elsevier ,1995
- Sequence and spacing requirements of a retrovirus integration siteJournal of Molecular Biology, 1988