The Random Urine Estrogen/Creatinine Ratio

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Abstract
Study was made of the potential clinical utility of a random urine estrogen/creatine (E/C) ratio as an index of fetal welfare. Detailed analysis of estriol, total estrogen, and creatinine measurements as determined on biweekly 24-hour and paired random urine samples in 20 pregnant subjects during the last 20 weeks of pregnancy was carried out. Results revealed that total urinary estrogen excretion bore a relatively constant relationship to estriol excretion, that 24-hour creatinine excretion remained quite constant, and that values of E/C ratio in the 24-hour urine and the paired random urine demonstrated excellent correlation. It was possible to predict the 24-hour urine E/C ratio from the paired random urine E/C ratio to within less than ±5 with 95% confidence. A proposed practical approach to the use of the random urine E/C ratio as an index of fetal welfare is presented.

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