TRANSFORMATION IN VITRO OF [4-14C]DEHYDROEPIANDROSTERONE TO 7-OXYGENATED DERIVATIVES BY NORMAL EARLY HUMAN PLACENTAL TISSUE

1 June 1971

journal article
Published by Bioscientifica in Journal of Endocrinology

Vol. 50 (2) , 301-306
https://doi.org/10.1677/joe.0.0500301

Abstract

SUMMARY: Samples from three early human placentae were incubated with [4-¹⁴C]-dehydroepiandrosterone (DHA). It was found that [4-¹⁴C]DHA was transformed into 7-oxygenated derivatives in yields decreasing in the order: 7-oxo-DHA > 7β-hydroxy-DHA > 7α-hydroxy-DHA. These products were only slowly transformed into other derivatives.

Keywords

DEHYDROEPIANDROSTERONE
14C
OXYGENATED
HUMAN PLACENTAL
EARLY HUMAN
HYDROXY DHA
NORMAL EARLY
OXO DHA
7Β HYDROXY

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