Investigating cardiovascular risk reduction – the Rosuvastatin GALAXY Programme™
- 1 May 2004
- journal article
- clinical trial
- Published by Informa Healthcare in Expert Opinion on Pharmacotherapy
- Vol. 5 (5) , 1187-1200
- https://doi.org/10.1517/14656566.5.5.1187
Abstract
The GALAXY Programme™ is a comprehensive global research initiative that will address several important unanswered questions in statin research and investigate the impact of rosuvastatin on cardiovascular risk reduction and patient outcomes. Studies already completed demonstrate that rosuvastatin provides greater reductions in low-density lipoprotein cholesterol (LDL-C) than other statins, enabling more patients to achieve LDL-C treatment goals. Additionally, rosuvastatin provides beneficial effects on other components of the atherogenic lipid profile. Ongoing studies will evaluate whether these effects translate into beneficial effects on atherosclerosis and significant reductions in cardiovascular events. Important information will also be provided on the role of statins in less well studied groups, including patients with heart failure, end stage renal disease, and individuals without elevated LDL-C but at heightened vascular risk as a result of increased systemic inflammation. Ultimately, the GALAXY P...Keywords
This publication has 24 references indexed in Scilit:
- Lipid-lowering therapy: strategies for improving complianceCurrent Medical Research and Opinion, 2004
- ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing CholesterolCirculation, 2002
- Frequency of congestive heart failure in older persons with prior myocardial infarction and serum low-density lipoprotein cholesterol ≥125 mg/dl treated with statins versus no lipid-lowering drugThe American Journal of Cardiology, 2002
- Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemiaExpert Opinion on Investigational Drugs, 2002
- Selectivity of ZD4522 for inhibition of cholesterol synthesis in hepatic versus non-hepatic cellsAtherosclerosis, 2000
- Single- and multiple-dose pharmacokinetics and safety of the new HMG-CoA reductase inhibitor ZD4522Atherosclerosis, 2000
- Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol LevelsNew England Journal of Medicine, 1998
- Comparative Dose Efficacy Study of Atorvastatin Versus Simvastatin, Pravastatin, Lovastatin, and Fluvastatin in Patients With Hypercholesterolemia (The CURVES Study) fn1fn1This study was supported by Parke-Davis, Division of Warner Lambert Company, Morris Plains, New Jersey. Manuscript received August 20, 1997; revised manuscript received and accepted November 24, 1997.The American Journal of Cardiology, 1998
- The effects of simvastatin on the incidence of heart failure in patients with coronary heart diseaseJournal of Cardiac Failure, 1997
- Effect of simvastatin on coronary atheroma: the Multicentre Anti-Atheroma Study (MAAS)The Lancet, 1994