ACETYLENIC AND ALLENIC DERIVATIVES OF 2-(1-METHYLINDOLYL) METHYLAMINE AS SELECTIVE INHIBITORS OF THE MONOAMINE OXIDASE-A AND OXIDASE-B

  • 1 July 1988
    • journal article
    • research article
    • Vol. 43  (7-8) , 567-573
Abstract
This paper reports the syntheiss of a new series of acetylenic and allenic derivatives of 2-(1-methylindolyl)methylamine as well as the preliminary results of their study as selective inhibitors of the A and B forms of the mitochondrial monoamine oxidase from bovine brain. The compounds were obtained from 2-(1-methylindole)carboxylic acid which, as its acyl halide, reacts with amines to give the respective amides. The latter compounds were reduced with lithium aluminium hydride to the respective amines (11 a-c) and then N-alkylated by reaction with 2-propynyl-, 2-butynyl- or 2,3-butadienyl bromides to the corresponding amines (III a-j).

This publication has 0 references indexed in Scilit: