Effects of Hypertonic Glucose and Mannitol on Plasma Volume.

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Abstract
Summary The influence of hyper tonic glucose and mannitol on blood volume was tested in normovolemic-normotensive and hypovo-lemic-hypotensive dogs. Neither glucose nor mannitol had any effect on the blood volume of normovolemic dogs. In hypovolemic-hypo-tensive dogs, mannitol produced a significant increase in the plasma volume by mobilizing fluid from the extravascular spaces. The fluid entering the circulation was accompanied by a significant amount of protein. Also, plasma volume increased after hemorrhage with glucose, but the increase was small and was not accompanied by protein. Thus, both glucose and mannitol, but particularly the latter, increased the blood volume in hypovolemia.