THE INFLUENCE OF 11-DEHYDR0-17-HYDR0XYCORTICOSTERONE (COMPOUND E) ON THE GROWTH OF A MALIGNANT TUMOR IN THE MOUSE11

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Abstract
The adm. of Compound E produces a retardation of growth of these completely refractory tumors but in every case the tumor eventually caused the death of the animal. At the present time the results indicate that the refractory state is inherent in the tumor cell and does not depend on the host. No means are known by which a tumor cell which has acquired resistance can be influenced by the hormone. The definite statement can be made that present knowledge does not furnish grounds for a successful extension of the results in the field of therapeutics. As described in this paper, the marked effects of the cortical hormone were limited to one tumor of the lymphatic system. These effects are exerted also on another tumor of the lymphatic system. The recent reports by Murphy and Sturm (1943; 1944) also indicate a hormonal control of the lymphoid system which is exerted by the adrenal cortex. Although ll-dehydro-17-hydroxycorticosterone is not yet available through synthetic means, recent progress toward that objective has been made.

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