Asymmetric Synthesis via Heterocyclic Intermediates, LII. Synthesis of tert‐Leucine and Related Amino Acids
- 13 July 1993
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1993 (7) , 715-719
- https://doi.org/10.1002/jlac.1993199301117
Abstract
The 2,5‐dialkoxypyrazines 3a and b were prepared in three steps from methyl glycinate hydrochloride (1) in an overall yield of 18 and 63%. Upon the addition of lithium organyls to 3b and subsequent acidic hydrolysis the ethyl glycinates rac‐7 were obtained.Keywords
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