aS,7S‐absolute configuration of natural (−)‐colchicine and allocongeners
- 12 March 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 262 (1) , 5-7
- https://doi.org/10.1016/0014-5793(90)80139-a
Abstract
The aS,7S-absolute configuration of (−)-colchicine (1) and (−)-N-acetylcolchinol methyl ether (3, NCME) suggested on the basis of 1H NMR data and negative Cotton effects at about 260 nm (EtOH) is firmly established by an X-ray analysis of urea 5, a compound derived from 3. Binding of these compounds to tubulin requires an aS-configuration of the biaryl systemKeywords
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