Rapid and Stereoselective C-C, C-O, C-N and C-S Couplings via Microwave Accelerated Palladium-Catalyzed Allylic Substitutions
- 31 December 2000
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2000 (07) , 1004-1008
- https://doi.org/10.1055/s-2000-6298
Abstract
Palladium-catalyzed substitution of cyclohex-2-en-1-yl ethyl carbonate with neutral C-, O-, and N-nucleophiles was achieved in 1 - 2 minutes using microwave flash heating. Enantioselectivities up to 96% were observed. Ionic nucleophiles tended to result in lower ee. With S-nucleophiles problems with the stability of the nucleophile were encountered.Keywords
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