Analgesic activity of anticancer agent suramin
- 1 April 1992
- journal article
- Published by Wolters Kluwer Health in Anti-Cancer Drugs
- Vol. 3 (2) , 91-94
- https://doi.org/10.1097/00001813-199204000-00003
Abstract
Suramin exhibited morphine-like analgesic activity in mice. It antagonized both thermal (hot-plate) and acetic acid-evoked writhing responses with ED50 values 1/100 and 1/68, respectively, that of morphine. The suramin- and morphine-induced hot-plate analgesia was suppressed by administration of 0.5 mg/kg naloxone. However, lower doses (5-30 micrograms/kg) of naloxone produced dose-related potentiation or suppression of suramin and morphine analgesia. This potentiation effect may be due to the inhibition of writhing by naloxone itself rather than be a direct antagonism of the morphine effect.Keywords
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