Influence of lipophilic counter ions on the transport of ionizable hydrophilic drugs
- 1 March 1991
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 43 (3) , 204-206
- https://doi.org/10.1111/j.2042-7158.1991.tb06667.x
Abstract
The influence of lipophilic counter ions on the transport of the hydrophilic drugs pholedrine and bretylium across artificial lipid membranes has been studied using a permeation model system. The transport of both drugs was markedly enhanced by hexylsalicylate and by salts of fatty acids with a maximum at decanoate. The transport of pholedrine was additionally increased by bile salts such as desoxycholate.Keywords
This publication has 5 references indexed in Scilit:
- Ion Pair Transport Across MembranesPharmaceutical Research, 1989
- Facilitated transfer of cationic drugs across a lipoidal membrane by oleic acid and lauric acidInternational Journal of Pharmaceutics, 1987
- Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in manJournal of Pharmacokinetics and Biopharmaceutics, 1984
- The influence of bile salts on the absorption in vitro and in vivo of propranololJournal of Pharmaceutical and Biomedical Analysis, 1984
- Bretylium pharmacokinetics and bioavailabilities in man with various doses and modes of administrationBiopharmaceutics & Drug Disposition, 1982