Demonstration of antibodies against Yersinia enterocolitica lipopolysaccharide in human sera by enzyme-linked immunosorbent assay

Abstract
Antibodies against Y. enterocolitica serotype O:3 lipopolysaccharide [LPS] present in sera from patients with Yersinia infection were studied using an enzyme-linked immunosorbent assay. Of the sera with significant bacterial agglutination titers against Y. enterocolitica type O:3, 86% contained anti-LPS IgG antibodies. The sera of some patients demonstrated increasing anti-LPS IgG antibody levels despite decreasing bacterial agglutination titers. The assay was specific for Y. enterocolitica type O:3 LPS and in inhibition experiments LPS could be detected in amounts of .gtoreq. 0.5 .mu.g/ml.

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