Regulatory networks defining EMT during cancer initiation and progression
Top Cited Papers
- 24 January 2013
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 13 (2) , 97-110
- https://doi.org/10.1038/nrc3447
Abstract
Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during development, but is an unintentional behaviour of cells during cancer progression. The EMT-associated reprogramming of cells not only suggests that fundamental changes may occur to several regulatory networks but also that an intimate interplay exists between them. Disturbance of a controlled epithelial balance is triggered by altering several layers of regulation, including the transcriptional and translational machinery, expression of non-coding RNAs, alternative splicing and protein stability.Keywords
This publication has 199 references indexed in Scilit:
- Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosisBiochemical and Biophysical Research Communications, 2012
- EMT and Dissemination Precede Pancreatic Tumor FormationCell, 2012
- In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of MelanomaCell, 2011
- Role of androgen receptor and associated lysine‐demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancerMolecular Carcinogenesis, 2011
- Twist1-Induced Invadopodia Formation Promotes Tumor MetastasisCancer Cell, 2011
- Epithelial-Mesenchymal Transitions in Development and DiseaseCell, 2009
- Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem CellsCell, 2009
- Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and InvasionCancer Cell, 2009
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem CellsPublished by Elsevier ,2008
- Modulation of several waves of gene expression during FGF‐1 induced epithelial‐mesenchymal transition of carcinoma cellsJournal of Cellular Biochemistry, 2008