Promiscuous regulator of xenobiotic removal.
- 1 May 2001
- journal article
- editorial
- Published by Springer Nature in Nature Medicine
- Vol. 7 (5) , 536-7
- https://doi.org/10.1038/87856
Abstract
No abstract availableThis publication has 9 references indexed in Scilit:
- The orphan nuclear receptor SXR coordinately regulates drug metabolism and effluxNature Medicine, 2001
- The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicityProceedings of the National Academy of Sciences, 2001
- Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemiaThe Lancet, 2000
- St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptorProceedings of the National Academy of Sciences, 2000
- Environmental Xenobiotics and the Antihormones Cyproterone Acetate and Spironolactone Use the Nuclear Hormone Pregnenolone X Receptor to Activate the CYP3A23 Hormone Response ElementMolecular Pharmacology, 1998
- SXR, a novel steroid and xenobioticsensing nuclear receptorGenes & Development, 1998
- The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.Journal of Clinical Investigation, 1998
- Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestineProceedings of the National Academy of Sciences, 1997
- P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.Proceedings of the National Academy of Sciences, 1996