THE QUANTITATIVE ESTIMATION OF TOTAL IRON STORES IN HUMAN BONE MARROW

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Abstract
An isotopic dilution technique was used to determine the storage iron content of the bone marrow in 61 subjects. The mean value for white males was 288 mg as compared with 99 mg for white females. The high incidence of iron over-load in Bantu males was reflected by a mean value of 1629 mg for this group. Further studies revealed a close correlation between storage iron concentrations in the marrows and livers of 199 necropsy subjects. There was moderately good agreement between histological evaluation of marrow iron stores and chemical determination of iron concentrations.