Susceptibility of the Diabetic Nerve to Chronic Compression

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Abstract
This study tested the hypothesis that the peripheral nerve in the presence of diabetes is more susceptible to chronic nerve compression than it is in the nondiabetic rat. A 1-cm length of sciatic nerve was subjected to chronic compression by banding with a Silastic tube in normal and in streptozotocin-induced diabetic rats. After six months of banding, both the amplitude and conduction velocity of the diabetic banded sciatic nerve were significantly reduced (p < 0.001) in comparison with the nondiabetic banded rats. These results suggest that in the presence of hyperglycemia, the peripheral nerve is more susceptible to chronic compression.

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