Plasma Glucagon Levels in Exercising Man

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Abstract
THE hyperglycemic, glycogenolytic and gluconeogenic actions of glucagon have been recognized for some time.1 The physiologic importance of this hormone, however, has only recently been substantiated with the evidence of increased circulating levels of glucagon during starvation2 and after protein3 and amino acid administration.4 In the present study the spectrum of alpha-cell function was further extended with the demonstration of increased levels of pancreatic glucagon in association with physical exertion.MethodsSeven non-obese, healthy adult male volunteers were studied in the postabsorptive state, after an overnight fast of 12 to 14 hours. Single-leg exercise was performed in the sitting position . . .