Single lead acetate insult, testosterone therapy, and erythropoiesis in mice

Publisher Website
Google Scholar
Abstract
Lead acetate (PbAc) was tested for its effects on the production and release of erythrocytes, i.e., erythropoiesis in ICR mice. Dose-survival data indicate that a dosage of 20 mg PbAc/100 g body wt represents the maximum tolerable treatment level. No differences in survival at the various levels of the salt were observed with regard to sex or age. For erythropoietic effects of PbAc, mice were injected on day 0, and 59Fe incorporation precentages were determined at daily intervals through day 8 for both erythrocytes and splenic tissue. Control mice received isotonic saline as the injectate. On day 3, the precentages obtained from PbAc-treated mice showed a decline, reaching their minimum value by day 4. Recovery from erythropoietic suppression appeared to be complete by day 6 or 7; no positive overshoots in 59Fe percentages were found following recovery. These trends were typical for both peripheral red blood cells and spleen. Testosterone was administered to mice receiving saline or PbAc on 2 consecutive days (days -1 and 0). 59Fe uptake percentages for females receiving testosterone and saline showed an abrupt increase on day 4. No accelerative effect due to testosterone was found in recipient males. For females treated with testosterone and PbAc, the 59Fe percentages for erythrocytes and spleen paralleled those for females receiving saline only. Male mice treated with both androgen and PbAc demonstrated 59Fe percentages typical of males treated with PbAc alone.

This publication has 19 references indexed in Scilit: