Increased Basal Ganglia Iron Levels in Huntington Disease
Open Access
- 1 May 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 56 (5) , 569-574
- https://doi.org/10.1001/archneur.56.5.569
Abstract
HUNTINGTON disease (HD) is a genetic disease caused by the repetition of a CAG trinucleotide sequence encoding for a polyglutamine tract at the N terminal of the gene coding for a protein of unknown function named huntingtin. Despite our understanding of the genetics of HD, the pathogenesis that results in the observed phenotypes remains puzzling, encumbering the search for therapeutic interventions.Keywords
This publication has 29 references indexed in Scilit:
- Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in miceJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1997
- Use of desferrioxamine in the treatment of aceruloplasminemiaAnnals of Neurology, 1997
- Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjectsPsychiatry Research: Neuroimaging, 1996
- Mitochondria, free radicals, and neurodegenerationCurrent Opinion in Neurobiology, 1996
- T1 and T2 of ferritin solutions: Effect of loading factorMagnetic Resonance in Medicine, 1996
- The quantitative Relation Between T1‐Weighted and T2‐Weighted MRI of Normal gray Matter and iron concentrationJournal of Magnetic Resonance Imaging, 1995
- MR microscopy at 7.0 T: Effects of brain ironJournal of Magnetic Resonance Imaging, 1991
- Nuclear magnetic resonance relaxation in experimental brain edema: Effects of water concentration, protein concentration, and temperatureMagnetic Resonance in Medicine, 1988
- Transverse relaxation of solvent protons induced by magnetized spheres: Application to ferritin, erythrocytes, and magnetiteMagnetic Resonance in Medicine, 1987
- The importance of free radicals and catalytic metal ions in human diseasesMolecular Aspects of Medicine, 1985