Studies on anticoccidial agents. VII. An improved synthesis of .ALPHA.4-norpyridoxol.
- 31 December 1975
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 24 (5) , 1089-1093
- https://doi.org/10.1248/cpb.24.1089
Abstract
The Diels-Alder reaction of 5-ethoxy-4-methyloxazole with unsymmetrical dienophiles was investigated and steric interaction during the course of the Diels-Alder reaction of an unsymmetrical dienophile with oxazole affected the structural isomeric distribution of the resulting products. On the basis of the above result, .alpha.4-norpyridoxol was synthesized by the Dields-Alder reaction of 5-ethoxy-4-methyloxazole with allyl alcohol or its derivatives. With the latter, acid hydrolysis of the adduct was necessary to obtain the title compound.This publication has 1 reference indexed in Scilit:
- Modification at the 2-Position of 4-Deoxypyridoxol and α4-NorpyridoxolAgricultural and Biological Chemistry, 1976