Response of the Level of Acid Mucopolysaccharides in Rat Granulation Tissue to Cortisol

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Abstract
Wet weight, dry weight, total nitrogen and the content of acid mucopolysaccharides of granulomas induced by cotton ball implantation in adrenalectomized untreated and cortisol-treated rats were determined. It was found that greater decreases occurred in the level of acid mucopolysaccharides (73 %) than in total nitrogen (56%), dry weight (61%) or wet weight (34%) in the treated animals. Although little or no change occurred in the actual quantities of total nitrogen per unit weight, the level of acid mucopolysaccharides was reduced by approximately 29 %. It would appear that cortisol can specifically affect the content of acid mucopolysaccharides in granulation tissue induced by cotton pledgets.