Michael addition as the key step in the syntheses of sialyloligosaccharide–protein conjugates from N-acryloylated glycopyranosylamines
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 1709-1711
- https://doi.org/10.1039/c39900001709
Abstract
Sialic acid and sialyloligosaccharides having terminal N-acryloyl functionality in their aglycone portions were efficiently conjugated to the lysine groups of proteins through Michael additions under mild basic conditions; the same N-acryloyl precursors were also polymerized with acrylamide to form serologically useful antigens.Keywords
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