Adrenergic Signal Transduction in Aging Parotid and Submandibular Salivary Glands

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Abstract
This study assessed agonist-and post-receptor-stimulated adenylate cyclase (AC) activity in parotid and submandibular salivary glands from female F-344 rats of 3,12, and 24 months of age. Isoproterenol-stimulated dose-response activation of adenylate cyclase was unchanged between 3 and 12 months but decreased at 24 months (p p≤ .05). Forskolin-stimulated AC activity, representing catalytic unit activity, was decreased at 24 months in the parotid (p p≤ .05) and at 12 months (p p≤ .05) and 24 months (p p≤ .01) in the submandibular gland,β-adrenergic signal transduction in salivary glands stimulates the secretion of salivary proteins that have important functions in the maintenance of oral health.

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