Estrogen receptor protein in malignant carcinoid tumor a report of 2 cases
- 15 January 1980
- Vol. 45 (2) , 293-296
- https://doi.org/10.1002/1097-0142(19800115)45:2<293::aid-cncr2820450216>3.0.co;2-5
Abstract
Two cases of metastatic malignant carcinoid tumor in elderly women contained significant amounts of estrogen receptor (19 and 32 femtomoles/mg protein) as shown by Scatchard-plot analysis of a dextran-coated charcoal assay, inhibition of binding by an estrogen analog (67 and 63%) and high-affinity binding (Kd = 6.8 and 2.6 × 10−10 M). The demonstration of estrogen receptor in malignant carcinoid tumor expands the spectrum of non-breast or non-gynecologic neoplasms that contain the receptor. The significance of estrogen receptor in such tumors is uncertain; it may represent aberrant derepression of the gene for estrogen receptor protein in a malignant tumor.This publication has 11 references indexed in Scilit:
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