The retention of an oral dose of radioactive manganese in the pullet and the effects on retention of the intake of inactive manganese

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Abstract
Droppings collected from pullets fed on a high-manganese diet contained 91.2% of an oral dose of Mn54 m the first 24 hr. and very small amounts In subsequent 24 hr. collections. Laying pullets that were fed on low- or high-Mn diets, were given a dose of radioactive manganese in solution with small or large amounts of inactive Mn and were killed 24 or 48 hr. after dosing. The mean percentage recovery of radioactive Mn in the droppings and gut contents was 92%. There were no differences among treatments. The mean Mn52 content of the liver was 0.60% of the dose. There was significantly more in the livers of birds fed on the low-Mn diet (0.85%) than in those of birds fed on the high-Mn diet (0.35%), but the difference caused by varying the concentration of Mn in the dose solution was not significant. The concentration of radioactive Mn in the blood, though always low relative to the dose, reached a maximum in most birds 6-8 hr. after the dose. Treatment effects were similar to those for the liver.

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