OVULATION INDUCED BY A GONADOTROPIN RELEASING HORMONE ANALOG IN HYPOPHYSECTOMIZED RATS INVOLVES PROSTAGLANDINS.
- 1 January 1982
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 110 (1) , 288-290
- https://doi.org/10.1210/endo-110-1-288
Abstract
A potent analogue of gonadotropin releasing hormone [D-Ala6- Des-Gly10-NH2]-GnRH ethylamide (GnRHa) caused oocyte maturation and ovulation when injected in the afternoon of proestrus in immature PMSG-treated female rats, hypophysectomized on the morning of proestrus. This action of GnRHa was accompanied by a marked increase in ovarian PGE levels. Furthermore, the pretreatment of the animals with a prostaglandin synthetase inhibitor (indomethacin) completely inhibited this PGE increase and ovulation. These data suggest a role for prostaglandins in GnRHa induced ovulation.Keywords
This publication has 2 references indexed in Scilit:
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- Similar luteinizing hormone-releasing hormone binding sites in rat anterior pituitary and ovary.Proceedings of the National Academy of Sciences, 1980