EFFECT OF HYPOPHYSECTOMY ON NEUROMUSCULAR FUNCTION

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Abstract
In rats hypophysectomy caused a decline of the amplitude and area of muscle action potential during repetitive indirect stimulation. This decrease occurred with relatively low frequency stimulation and was even more evident with increased frequency of stimulation. On indirect stimulation the decrease of muscle action potential paralleled the decrease of the magnitude of contraction. The magnitude of muscle contraction on direct stimulation decreased less than on indirect stimulation. It is inferred that the neuromuscular fatigue occurring in hypophysectomized animals is due to both a moderate dysfunction of the muscle and a marked dysfunction of the nerve element (either nerve or myoneural junction).

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