SPECIFIC POTENTIATION OF L1210 VACCINE BY PYRAN COPOLYMER

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (6) , 2035-2039
Abstract
Pyran copolymer (NSC-46015) potentiated the immune response of C57BL/6J .times. DBA/2 F1 mice to 104 live L1210 leukemia cells following suboptimal vaccination with 107 radiation-inactivated L1210 cells. Optimal immunity to challenge was produced by concomitant i.p. administration of pyran and L1210 vaccine, and activity was dependent on pyran and vaccine dosages. This immunopotentiation seemed to be related to the intrinsic viscosity of different pyran preparations tested, although all pyran compounds had significant activity. The increased immunity to subsequent live tumor challenge appeared to be specific for the vaccinating cell type.