Clinical, Bacteriological, and Serological Observations of two Human Volunteers Following Ingestion of Escherichia coli

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Abstract
The ingestion of 4 to 8 million 0127:B8 organisms by 2 adult male volunteers results in symptoms of mild to moderate gastroenteritis with excretion of organisms in the stool for as long as 12 days. Hemagglutinins were detected 3 days and bacterial agglutinins 5 days after ingestion, with peak titers by the 8th to 9th day. Hemagglutinin titers were consistently higher than bacterial agglutinin titers. Challenge ingestion was followed by bacterial and serological response without clinical symptoms.