Melatonin Synthesis: Adenosine 3′,5′-Monophosphate and Norepinephrine Stimulate N -Acetyltransferase
- 22 May 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3934) , 979-980
- https://doi.org/10.1126/science.168.3934.979
Abstract
Treatment of cultured rat pineal glands with norepinephrine or dibutyryl adenosine 3',5'-monophosphate causes a six- to tenfold stimulation of N-acetyltransferase. This enzyme converts serotonin to N-acetylserotonin, the immediate precursor of melatonin. The increased synthesis of melatonin caused by norepinephrine treatment appears to be the result of stimulation of N-acetyltransferase by an adenosine 3',5'-monophosphate mechanism.Keywords
This publication has 12 references indexed in Scilit:
- Cyclic Adenosine Monophosphate: Stimulation of Melatonin and Serotonin Synthesis in Cultured Rat PinealsScience, 1969
- Adenyl Cyclase and Phosphodiesterase Activities in Brain Areas of Man, Monkey and RatThe Lancet Healthy Longevity, 1969
- Acetylation of 5-hydroxytryptamine by isoniazid N-acetyltransferaseBiochimica et Biophysica Acta (BBA) - General Subjects, 1969
- Thin-layer chromatographic separation of pineal gland derivatives of serotonin-14CAnalytical Biochemistry, 1969
- Regional and subcellular distribution of adenyl cyclase and 3',5'-cyclic nucleotide phosphodiesterase in brain and pineal glandBiochemical Pharmacology, 1968
- Cyclic AMPAnnual Review of Biochemistry, 1968
- Photic and Neural Control of Indoleamine Metabolism in the Rat Pineal GlandPublished by Elsevier ,1968
- Adenyl Cyclase Activity in Rat Pineal Gland: Effects of Chronic Denervation and NorepinephrineScience, 1967
- Derivatives of cyclic 3′,5′-adenosine monophosphateBiochimica et Biophysica Acta, 1962
- The enzymic acetylation of serotonin and other naturally ocurring aminesBiochimica et Biophysica Acta, 1961