Protein aggregation and bioprocessing
Top Cited Papers
- 1 September 2006
- journal article
- review article
- Published by Springer Nature in The AAPS Journal
- Vol. 8 (3) , E572-E579
- https://doi.org/10.1208/aapsj080366
Abstract
Protein aggregation is a common issue encountered during manufacture of biotherapeutics. It is possible to influence the amount of aggregate produced durinKeywords
This publication has 23 references indexed in Scilit:
- Effect of Copper Sulfate on Performance of a Serum-Free CHO Cell Culture Process and the Level of Free Thiol in the Recombinant Antibody ExpressedBiotechnology Progress, 2008
- Effects of protein aggregates: An immunologic perspectiveThe AAPS Journal, 2006
- What factor drives the fibrillogenic association of β‐sheets?FEBS Letters, 2005
- Reversible Self-Association Increases the Viscosity of a Concentrated Monoclonal Antibody in Aqueous SolutionJournal of Pharmaceutical Sciences, 2005
- Separation of monoclonal antibody alemtuzumab monomer and dimers using ultrafiltrationBiotechnology & Bioengineering, 2005
- Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodiesDrug Development Research, 2004
- Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulationsAAPS PharmSci, 2003
- Free Sulfhydryl in Recombinant Monoclonal AntibodiesBiotechnology Progress, 2002
- Disulfide-Linked Oligomerization of Basic Fibroblast Growth FactorPublished by American Chemical Society (ACS) ,1994
- THE PHOTOPHYSICS AND PHOTOCHEMISTRY OF THE NEAR‐UV ABSORBING AMINO ACIDS–II. TYROSINE AND ITS SIMPLE DERIVATIVESPhotochemistry and Photobiology, 1984