Dementia and Borna Disease Virus

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Abstract
Human Borna disease virus (BDV) infection has been reported to be a threat to mental health [1]. BDV is an unclassified, nonsegmented negative sense single-stranded RNA virus which naturally infects horses, cattle, cats and sheep [2, 3]. Infection causes disturbances in behavior and cognitive function [1]. Recently, seroepidemiological and molecular evidence of BDV infection has been found in humans with psychiatric disorders [4, 5], although healthy people also have a low prevalence of BDV genome and anti-BDV antibodies [6, 7]. Patients with dementia also have disturbed behavior and cognitive function. For the first time, we investigated the relationship between dementia and BDV infections.