Fendosal and aspirin in postpartum uterine pain

Publisher Website
Google Scholar
Abstract
The analgesic efficacy of fendosal, a new nonsteroidal anti-inflammatory agent structurally related to salicylic acid, was compared with that of aspirin and placebo in 100 patients with postpartum uterine pain in a single oral dose, parallel, stratified, randomized, double-blind design. With 650 mg aspirin and with 200 or 400 mg fendosal, but not with 100 mg, analgesic effects, as measured subjectively by mean pain intensity scores, began within 1 hr and had similar time-effect patterns for the first 4 or 5 hr. Thereafter with the 2 higher doses of fendosal analgesia continued to increase, reaching a peak at 6 hr (p < 0.05) and persisting beyond 7 hr (p < 0.01), whereas there was no aspirin analgesia after the fifth hour. With 100 mg fendosal time of onset tended to be delayed 2 hr or more, and duration was short. The most effective treatment (largest mean 7-hr sum of pain intensity difference [SPID] score) was 400 mg fendosal (p < 0.01); 200 mg fendosal was rated second (p < 0.01), 650 mg aspirin, third (p < 0.05), 100 mg fendosal, fourth, and placebo, fifth. There were no significant side effects. These results demonstrate the efficacy of single doses of fendosal as well as the dose-dependent magnitude and time course of effect on postpartum uterine pain.

This publication has 1 reference indexed in Scilit: