The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Top Cited Papers
- 18 April 2004
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 10 (5) , 484-486
- https://doi.org/10.1038/nm1042
Abstract
The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.Keywords
This publication has 12 references indexed in Scilit:
- An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten+/−miceProceedings of the National Academy of Sciences, 2001
- Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTORProceedings of the National Academy of Sciences, 2001
- TOR, a Central Controller of Cell GrowthCell, 2000
- Expression of the Eukaryotic Translation Initiation Factors 4E and 2α in Non-Hodgkin's LymphomasThe American Journal of Pathology, 1999
- Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2The EMBO Journal, 1997
- Translational Control of Programmed Cell Death: Eukaryotic Translation Initiation Factor 4E Blocks Apoptosis in Growth-Factor-Restricted Fibroblasts with Physiologically Expressed or Deregulated MycMolecular and Cellular Biology, 1996
- A biomarker that identifies senescent human cells in culture and in aging skin in vivo.Proceedings of the National Academy of Sciences, 1995
- Induction of apoptosis in fibroblasts by c-myc proteinCell, 1992
- The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.Molecular and Cellular Biology, 1992
- Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' capNature, 1990