Estrogen Response and Pigmentation of the Uterus in Vit. E-Deficient Rat.

Publisher Website
Google Scholar
Abstract
Rats, born of vitamin E-deficient mothers, were ovariectomized at weaning and were maintained on a vitamin E-deficient diet for from 6 weeks to 10 months. No difference in the uterine wt. response to injd. estradiol benzoate was discernable between these animals and control animals maintained on the same diet supplemented with alpha-tocopherol acetate. The uterine wt. response to estrogen was significantly greater at 3 months of age than at 10 months regardless of tocopherol admn. Accumulation of acid-fast pigment in the uterus is characteristic of intact rats maintained on a vitamin E-deficient diet. Ovariectomy at weaning prevented the appearance of uterine pigmentation in animals maintained on the deficient diet for as long as 10 months.