Adenocarcinoma of the Endometrium Stage I

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Abstract
Survival after treatment of stage I endometrial adenocarcinoma was studied in a material of 111 patients, median follow-up period 6 yr. Routine treatment was preoperative intrauterine and vaginal Ra followed, in 6 wk by total hysterectomy and bilateral salpingo-oophorectomy. The 5-yr corrected survival after treatment by operation and/or irradiation was 93%, after irradiation alone 87%. A significantly better survival was found in stage Ia (95%) than in stage Ib (83%) and also in patients with grade 1 tumors (97%) than in those with grade 3 tumors (71%); 21% of the patients had a residual endometrial tumor after preoperative Ra, and among them survival was significantly lower than in patients without residual tumor. The recurrence rate was 11.7%. Vaginal metastases did not occur. Satisfactory results were obtained in stage I, grade 1 and 2. Supplementary treatment must be recommended in the case of grade 3 tumors, of myometrial deep invasion, and of residual tumor following preoperative radium therapy.