The individual variation in pharmacokinetics and pharmacodynamics of furosemide in young normal male subjects

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Abstract
Following a 24-h control period in the ward 80 mg furosemide was injected i.v. to 10 young, healthy male volunteers. The serum clearance of furosemide (Cls) was between 140-201 ml/min and on the average the renal clearance was 66% of Cls. During the initial 30-min period a maximum additional excretion rate of Na of 3.3 mmol/min was reached at an excretion rate of 0.8 mg furosemide/min. A marked initial drop in creatinine clearance (Clcr) was noted and 24 h Clcr showed an average decrease of 12% after the drug administration. The serum concentration of K decreased at 1 and 2 h after injection and of Na from 2 h on. The concentration of albumin in serum increased by 3% (P < 0.05) after 5 min. After 2 h a maximum increase of 14% was reached. After 8 min diastolic blood pressure was increased by 13% (P < 0.05), whereas systolic blood pressure reached a significant decrease gradually (7% after 3 h).

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