Simultaneous HPLC Analysis of Carbamazepine and Carbamazepine Epoxide in Human Brain Microdialysate

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Abstract
Intracerebral microdialysis has become a standard method for neurochemistry studies and is becoming recognized as an important new method for pharmacological studies. The technique permits repeated measurement of drug concentrations in the brain extracellular fluid with minimal disturbance of the neuronal environment. The sample volumes are exceedingly small, on the order of tens of microliters. This is countered by the purity of the samples, reducing the need for extraction prior to assay. We present a HPLC assay capable of reliably measuring the concentrations of the antiepileptic drug carbamazepine and its metabolites carbamazepine-10,11-epoxide and carbamazepine-10,11trans-diol.

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