Allosteric Modulation Bypasses the Requirement for ATP Hydrolysis in Regenerating Low Affinity Transition State Conformation of Human P-glycoprotein
Open Access
- 1 April 2006
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 281 (16) , 10769-10777
- https://doi.org/10.1074/jbc.m512579200
Abstract
No abstract availableKeywords
This publication has 37 references indexed in Scilit:
- An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modelingThe FASEB Journal, 2003
- Defining the Drug-binding Site in the Human Multidrug Resistance P-glycoprotein Using a Methanethiosulfonate Analog of Verapamil, MTS-verapamilJournal of Biological Chemistry, 2001
- Both ATP Sites of Human P-Glycoprotein Are Essential but Not SymmetricBiochemistry, 1999
- BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTERAnnual Review of Pharmacology and Toxicology, 1999
- Mutations in the Nucleotide-Binding Sites of P-Glycoprotein That Affect Substrate Specificity Modulate Substrate-Induced Adenosine Triphosphatase ActivityBiochemistry, 1998
- [38] ATPase activity of Chinese hamster P-glycoproteinPublished by Elsevier ,1998
- Both P-glycoprotein Nucleotide-binding Sites Are Catalytically ActivePublished by Elsevier ,1995
- BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTERAnnual Review of Biochemistry, 1993
- ABC Transporters: From Microorganisms to ManAnnual Review of Cell Biology, 1992
- Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cellsCell, 1986