Studies on Rat Liver Glutamine Synthetase
- 1 January 1969
- journal article
- research article
- Published by Wiley in Israel Journal of Chemistry
- Vol. 7 (1) , 85-88
- https://doi.org/10.1002/ijch.196900012
Abstract
Rat liver glutamine synthetase is activated by Mg++ and by Mn++. Optimal activity of the Mg++ activated synthetase occurred at about pH 7.8. The pH optimum of the Mn++ activated enzyme varied from 6.2 at low Mn++concentrations to 4.4 at high Mn++concentrations. α‐N‐Ethyl‐L‐glutamine inhibits the synthetase activity. The inhibition is of a mixed type. The synthetase is also inhibited, to a lesser degree, by α‐N‐propyl‐L‐glutamine but not by α‐N‐butyl‐L‐glutamine.Keywords
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