Biosynthesis of Monensin
Open Access
- 1 October 1973
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 4 (4) , 410-414
- https://doi.org/10.1128/aac.4.4.410
Abstract
The biosynthesis of monensin by Streptomyces cinnamonensis was studied by using 14 C-labeled glucose, acetate, propionate, butyrate, and methionine. The results indicated that the antibiotic is synthesized from five acetate, seven propionate, and one butyrate molecules. The o -methyl group of monensin is derived from methionine, whereas the terminal hydroxymethyl group is incorporated from acetate.Keywords
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