Depression, Psychopathy, and Herpesvirus Type I Antibodies

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Abstract
This study attempted to confirm earlier reports that antibody titers to the herpes simplex virus were significantly elevated in patients with depressive illness and psychopathic disorder. One hundred ninety-seven subjects were studied, including 62 patients with a diagnosis of depression and 29 patients with antisocial personality or emotionally unstable personality disorder. The methods of antibody assay included measurement of neutralizing antibodies and complement-fixation antibodies. No significant elevation of herpesvirus type I antibodies was found in either the depressive group or the personality disorder group. The incidence of antibody positive subjects and the titer levels tended to increase with age.

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