Antibiotic Usage in Patients with Renal Impairment

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Abstract
In renal disease the persistence of antibiotics, or their serum half-life, depends on the extent to which the kidneys effect their clearance. For drugs largely or moderately cleared by the kidneys, serum creatimine concentration provides a method of gauging persistence and of adjusting dose schedules to the needs of the renally compromised individual. In urinary tract infections, drugs must be selected that reach the urine in adequate concentrations for efficacy.

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