Clinical usefulness of free and complexed PSA

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Abstract
We selected serums from 51 fully characterized prostate cancer patients and 48 biopsy-proven BPH patients in order to test the abil ity of the ratio of the free/total PSA in distinguishing between CaP and BPH patients in the best case scenario. The 51 cancer patients had cancer volumes ranging from 2.0—17.8 mL and had a median % free PSA of 8.9%. The 48 BPH patients, which had prostate volumens ranging from 36.9—313.8 mL, had a median % free PSA of 16.5%. almost twice that of the CaP patients. We also examined the physiological variation of serums drawn on the same patient over a reasonably short time (mean of 22 days). The variation between consecutive redraws on the same patient was measured to be 30% (95% conficence interval) in the PSA range of 4—10 μg/L, measured on the Hybritech Tandem-R PSA Assay.