Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

1 January 1990

journal article
research article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 43 (1) , 8-18
https://doi.org/10.7164/antibiotics.43.8

Abstract

Streptomyces hygroscopicus No. P247-71 (ATCC 53709) produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L-serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.

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