Effect of gammahydroxybutyric acid on serotonin synthesis, concentration and metabolism in the developing rat brain
- 1 March 1983
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 57 (1-2) , 39-48
- https://doi.org/10.1007/bf01250046
Abstract
5-HT synthesis, levels and degradation were investigated in the whole brain and regional brain areas in 4,14, and 28 days old rats after administration of gammahydroxybutyric acid (GHBA). 5-HT synthesis was investigated by means of 5-HTP accumulation after decarboxylase inhibition by NSD 1015. 5-HTP accumulation increased in the 14 and 28 days old rats but decreased in the 4 days old animals 90 min after GHBA, 750 mg/kg. In the 28 days old rats a corresponding increase was also noted in the precursor amino acid tryptophan. Regional and whole brain 5-HT levels were not altered by GHBA treatment. Regional as well as whole brain levels of 5-HIAA increased in the 14 and 28 days old rats after GHBA administration. In conclusion, the present data indicate that GHBA increases the synthesis and degradation of 5-HT in adolescent rats. These effects of GHBA were not seen in the neonatal animals.This publication has 18 references indexed in Scilit:
- Effect of gammahydroxybutyric acid on catecholamine synthesis and utilization in the developing rat brainJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1982
- Ontogeny of γ-hydroxybutyric acid. I. Regional concentration in developing rat, monkey and human brainDevelopmental Brain Research, 1981
- Serotoninergic development in the postnatal rat brainJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1980
- Catecholamine Concentration in the Developing Rat Brain after ?-Hydroxybutyric AcidJournal of Neurochemistry, 1980
- Serotonin metabolism in neonatal rat brain during asphyxia and recoveryActa Physiologica Scandinavica, 1980
- Muscimol binding in rat brain: Association with synaptic GABA receptorsBrain Research, 1978
- A Procedure for the Isolation of Noradrenaline (together with Adrenaline), Dopamine, 5‐Hydroxytryptamine and Histamine from the Same Tissue Sample Using a Single Column of Strongly Acidic Cation Exchange ResinActa Pharmacologica et Toxicologica, 1978
- Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivoJournal of Pharmacy and Pharmacology, 1973
- Inhibitory effect of gammahydroxybutyric acid and gammaaminobutyric acid on the dopamine cells in the substantia nigraNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1973
- GABA UPTAKE IN RAT CENTRAL NERVOUS SYSTEM: COMPARISON OF UPTAKE IN SLICES AND HOMOGENATES AND THE EFFECTS OF SOME INHIBITORSJournal of Neurochemistry, 1971