Chromosome segregation from cell hybrids. III. Segregation is independent of spindle constitution
- 1 August 1987
- journal article
- research article
- Published by Canadian Science Publishing in Genome
- Vol. 29 (4) , 528-531
- https://doi.org/10.1139/g87-090
Abstract
Hamster β-tubulin (detected as a mutant subunit that confers Colcemid resistance) is either not expressed or is underexpressed in Chinese hamster–mouse somatic cell hybrids. This selectivity of tubulin expression suggests that a uniparental mouse spindle might preferentially engage mouse chromosomes and lead to loss of hamster chromosomes. However, the repression of hamster tubulin was found to have no bearing on the direction of chromosome segregation occurring in eight hybrids studied, some of which segregated predominantly mouse and others hamster chromosomes. Key words: chromosome segregation, cell hybrids, spindle, tubulin.This publication has 10 references indexed in Scilit:
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