Regulation of Interferon-γ Gene Expression

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Abstract
Interferon-gamma (IFN-γ), also known as type II interferon, is an important immunoregulatory gene that has multiple effects on the development, maturation, and function of the immune system. IFN-γ mRNA and protein are expressed predominantly by T cells and large granular lymphocytes. The IFN-γ mRNA is induced/inhibited in these cell types by a wide variety of extracellular signals, thus implicating a number of diverse, yet convergent signal transduction pathways in its transcriptional control. In this review, I describe how DNA methylation and specific DNA binding proteins may regulate transcription of the IFN-γ gene in response to extracellular signals.